The Murghab River, situated in the Murghab district of Tajikistan, is renowned for its high-altitude ecosystem and arctic-alpine climate. Originating from the eastern Pamir Mountains, it carves through the rugged terrains, with its headwaters near the borders of Afghanistan and China, eventually joining the Panj River, which then forms the Amu Darya River. This region is characterized by its stark, lunar-like expanses and sparse vegetation, providing a habitat for hardy wildlife species uniquely adapted to the cold desert environment. Human settlements along the riverbank rely on pastoralism and limited agriculture, with adaptation to harsh climatic conditions. The river is not only a lifeline for the inhabitants but also serves as a crucial water source for irrigation and sustaining local biodiversity. Despite the remote and harsh landscape, this area represents the unique interaction between nature and human resilience in one of Central Asia’s most imposing and dramatic settings.